2024, 89 (3)  p. 271-276

Nur Nabilah Mohd Zaini, Wan Mohd Nuzul Hakimi Wan Salleh, Abubakar Siddiq Salihu, Mohd Hafiz Arzmi

Abstract

The genus Lindera in the family Lauraceae, is widely distributed in tropical and subtropical areas throughout the world. Its roots and leaves have been used for thousands of years as a traditional Chinese medicine and functional food. This study was carried out to investigate the antioxidant, antifungal, and antibiofilm properties from Lindera subumbelliflora (Blume) Kosterm (leaves and roots) and L. caesia Reinw. ex Fern.-Vill. (leaves) growing in Malaysia. Antioxidant activity was determined using DPPH assay, antifungal activity by microdilution method for determination of MIC and MFC, whereas antibiofilm was determined using a semi-quantitative static biofilm. The L. caesia leaf extract revealed strong activity in DPPH assay with IC50 value of 65.6 μg mL-1, while the L. subumbelliflora roots extract exhibited the best antifungal activity against Candidca albicans ECE1 with MIC and MFC value of 250 μg mL-1. In addition, all Lindera extracts showed promising antibiofilm inhibitory activity against different Candida strains with biofilm inhibition values ranging from 50.2 to 78.0%. This study suggests that Lindera species might be an excellent source of antifungal, antibiofilm, and antioxidant drugs and would be helpful in minimizing the spreading of pathogenic microorganisms or preventing stress-related diseases.

Keywords

Lauraceae, Lindera, antioxidant, antifungal, biofilm, DPPH, Candida albicans

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