The interaction effect of haemoglobin genotypes (HbAA, HbAB) and residual feed intake (RFI) classes (RFILL, RFIMM, RFIHH) on feed efficiency, haematological and serum parameters in on-farm West African Dwarf (WAD) does was studied for pre-selection of breeding animals. Ninety-six does were fed for 112 days. Feed intake was measured daily, body weight and other variables were measured at 28-day intervals. Dry matter intake (DMI); average daily gain (ADG) and feed conversion efficiency (FCE) were computed while body condition score (BCS) was estimated using the five-point scale for goats. Blood samples were collected after 112 days via jugular vein puncture and analyzed for insulin-like growth factor (IGF-I), insulin, leptin, urea and complete cell counts. Phenotypic RFI was calculated for each animal as the residual from a multiple regression model of DMI on ADG and mid-test metabolic bodyweight (BW0.75). The WAD does with heterozygous HbAB genotype had higher serum insulin and IGF-1 concentrations than the homozygous HbAA genotype (P < 0.019). Does within the low RFI (RFILL) class recorded higher IGF-1 (P < 0.050 ), PCV (P < 0.002 ) and Hb concentration (P < 0.038) than does within the medium (RFIMM) and high (RFIHH) classes. The interaction of Hb genotype and RFI revealed significant differences (P < 0.050) on FCE, IGF-1 and monocytes values among does. The result of Hb genotype x RFI class interaction on RFI was not significant (P = 0.077), although values increased numerically in ascending order to rank does into pre-selection classes. WAD does of HbAA and HbAB genotypes with negative-RFI values (-0.004, -0.005) were deemed most efficient nutritionally and could be selected as parents.