This study investigated the nutrient composition of the seeds of two cultivars of Citrullis lanatus ('Rhotmas' and 'Sugar Baby') and compared it with Citrullus colocynthis. The moisture content, ash, crude fiber, ether extract, crude protein and true protein ranged from 5.43 to 6.82, 2.78 to 3.72, 1.66 to 3.94, 55.7 to 58.7, 19.16 to 25.18 and 10.8 to 13%, respectively. The starch content, total sugar and reducing sugar varied between 143.7 and 172.7, 53.7 and 96.5, 5.6 and 9.5 mg/g, respectively. Iron, copper, zinc, calcium and magnesium ranged from 191 to 211, 20.12 to 35.03, 68.97 to 92.57, 98.79 to 233, and 79.75 to 123.9 mg/kg, respectively. Heavy metals (lead and cadmium) and antinutrients (phytate, oxalate and cyanide) were below deleterious levels. Arginine, glutamic acid and aspartic acids were the most abundant amino acids, whereas lysine was the limiting amino acid. It is concluded that watermelon seeds were better in nutritional value compared to egusi melon seeds and therefore could be regarded as a potential sources of food if exploited.