The anthropogenic emission of greenhouse gases including carbon dioxide, methane, and nitrous oxide is bringing about major changes to the global environment. Although most of the anthropogenic emissions originate from industrial processes, agriculture is responsible for a significant portion of the greenhouse gases produced by humans worldwide. The impact of agriculture has become a key issue, considering that the main greenhouse gases are those related to carbon and nitrogen global cycles. This paper presents a review of the scientific literature meant to provide the impact of human management through fertilizers use on CO2, CH4, and N2O emissions. The influence of organic and mineral fertilization on greenhouse gas emissions is analyzed, and usage of organic amendments showed a wise potential for protecting the environment and to mitigate greenhouse gas emissions.