Two field experiments were carried out in 2015 and 2016 cropping seasons at the Teaching and Research Farm of Landmark University, Omu-Aran, Kwara state. The aim was to determine the effect of single and integrated application of poultry manure (PM), NPK and ZnSO₄ fertilizers on the agronomic performance, yield, some nutrient elements and heavy metal content of tomato (Lycopersicon esculentum Mill) in the derived savannah ecological zone of Nigeria. Treatments consisted of: 150 kg ha^-1 NPK + 15 t ha^-1 PM + 5 kgha^-1 Zn (T₁); 150 kg ha^-1 NPK + 15 t ha^-1 PM (T₂); 15 t ha^-1 PM ­­+ 5 kg ha^-1 Zn (T₃); 30 t ha^-1 PM (T₄); 150 kg ha^-1 NPK +­­ 5 kg ha^-1 Zn (T₅); 10 kg ha^-1 Zn (T₆); 300 kg ha^-1 NPK (T₇) and control (T₈). The contribution of integrated application of PM and NPK at lower rates on growth and yield of tomato was high while application of zinc at higher rate (10 kg ha^-1) increased the availability of some nutrient elements and heavy metals of tomato fruits though not beyond the permissible limits as established by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) to ensure food safety of the consumers. It can therefore be concluded that application of 150 kg ha^-1 NPK + 15 t ha^-1 PM + 10 Kg ha^-1 Zn is beneficial for tomato production in the study area without any threat to human health.