Phosphogypsum (PG) is a by-product of phosphoric acid production and according to the Waste Management Strategy of the Republic of Croatia for 2007 – 2015 (Official Gazette 85/07, 126/10, 31/11, 46/15) it is classified under the waste code 06 09 01. Phosphogypsum has a significant impact on the environment by its effects, admixtures (impurities) and amount. One of its possible applications is in agriculture. Many positive effects on soil and plants were noted, but there is also a growing concern regarding the effect of residues of heavy metals and natural radioactivity of radionuclides. In order to obtain a better understanding of this subject, this study provides a general overview of the available literature regarding the application of phosphogypsum in agriculture.